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Best sinus medicines - May 2026

Last Updated - May 19, 2026

1
Best Choice

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Amazon One Medical

Sinus Infection Treatment & Symptoms | Request prescription for sinus medication like nasal spray, antibiotics for sinus headache & pain symptom relief from an online doctor, NP, or PA

Amazon One Medical

$39.00

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Main highlights
- Treated with fda approved prescription drugs or otc medication like cleaner flush irrigation decongestant rinse clean out cefixime mometasone furoate Nasonex fluticasone propionate Flonase triamcinolone acetonide Nasacort intranasal ipratropium augmentin amoxicillin levaquin suprax omnicef oxymetazoline clavulanate doxycycline moxifloxacin levofloxacin cefdinir cefpodoxime clindamycin guaifenesin generic antibiotic
- Treated by online doctor, dr, MD, NP, PA. FSA/HSA reimburse for PPV. Adult human men man male hombre woman women
- Strengths like 100 mg 200 mg 250 mg 300 mg 400 mg 500 mg 600 mg 50 mcg 55 mcg 0.05 875 mg 125 mg 62.5 mg 5 ml 0.05%
- Pay per visit (PPV) telehealth telemedicine video, message. Membership option available. Previously Amazon Clinic
- Medicine forms like meds pills tablet tab capsule spray suspension
- Get medical care, diagnosis, remedy, relief, refill, help, cure sinus infection
$39.00
2

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Mucinex

Mucinex Maximum Strength Sinus-Max Severe Congestion & Pain + Nightshift Sinus Liquid, Cold and Flu Medicine for Adults, Over-the-Counter Medication for Multi-Symptom Relief, 2x6 Fl Oz

Mucinex

$26.99

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Main highlights
- USAGE: Use as directed; For ages 12+ years
- SINUS SYMPTOM NIGHT RELIEF: Mucinex Nightshift Sinus reduces fever, relieves sore throat, runny nose, sneezing, nasal congestion, and controls cough
- SEVERE CONGESTION & PAIN SYMPTOM RELIEF: Maximum Strength Mucinex Sinus-Max Severe Congestion & Pain helps relieve headache, sinus congestion and thin & loosen mucus
- POWERFUL MULTI-SYMPTOM RELIEF: This combo pack of Maximum Strength Mucinex Sinus-Max Severe Congestion & Pain and Mucinex Nightshift Sinus provides powerful multi-symptom relief for your worst sinus congestion symptoms
- MUCINEX SINUS-MAX SEVERE CONGESTION & PAIN ACTIVE INGREDIENTS: Contains Acetaminophen - Pain reliever; Guaifenesin - Expectorant; Phenylephrine HCI - Nasal decongestant
- MUCINEX NIGHTSHIFT SINUS ACTIVE INGREDIENTS: Contains Acetaminophen - Pain reliever and fever reducer; Dextromethorphan HBr - Cough suppressant; Phenylephrine HCI - Nasal decongestant; Triprolidine HCl – Antihistamine
- #1 TRUSTED COLD & COUGH BRAND: Mucinex is the #1 Cold and Cough brand doctors trust* and #1 Pharmacist Recommended Brand
$26.99
3
Best Value
18% Off

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Sudafed
18% Off

Sudafed PE Sinus Pressure Relief Plus Pain Relief Tablets, Maximum Strength, Non-Drowsy Decongestant, OTC Sinus Medicine with Acetaminophen and Phenylephrine HCl Nasal Decongestant, 24 CT

Sudafed

$8.71

$10.67
(18% Off)

More Details
Main highlights
- PHENYLEPHRINE HCL & ACETAMINOPHEN: Each sinus congestion and pressure relief tablet contains 5 mg of phenylephrine HCI, a nasal decongestant for non-drowsy relief, plus, 325 mg of acetaminophen, a pain & fever reducer
- NON-DROWSY COLD and SINUS MEDICINE: Sudafed sinus and pain medication helps to temporarily relieve nasal congestion associated with hay fever, upper respiratory allergies and the common cold, plus sinus headaches
- HOW TO USE: Sudafed PE sinus pressure and pain relief congestion relief tablets can be used by adults and children ages 12 and up. Take two tablets every four hours; do not exceed 10 tablets within a 24 hour time
- FSA HSA APPROVED PRODUCT: Sinus congestion relief & pain medicine from Sudafed, the #1 pharmacist recommended brand among oral OTC decongestants. Sudafed PE Sinus Pressure + Pain is HSA & FSA eligible** **Check your plan for details as plans may vary.
- DECONGESTANT & PAIN RELIEF: 24-count package of Sudafed PE Sinus Pressure and Pain maximum strength non-drowsy decongestant tablets for fast and powerful relief of sinus congestion, sinus pressure, and nasal congestion
$8.71
$10.67 (18% Off)
4

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Mucinex

Mucinex Rapid Clear Maximum Strength Cold Medicine & Expectorant, Fever, Pain, Headache, & Excess Mucus Relief with Acetaminophen & Guaifenesin, Rapid Release Caplets for Adults, 20 Count

Mucinex

$13.97

More Details
Main highlights
- RAPID RELEASE CAPLETS: Mucinex Rapid Clear caplets start working fast
- PAIN RELIEF: Acetaminophen helps reduce fever and helps relieve body aches and headache associated with cold and flu
- MAXIMUM STRENGTH & NON-DROWSY: With Mucinex Rapid Clear, it's not "power through with a pounding headache" season—It's comeback season
- HEADACHE RELIEF: Helps relieve headaches including those associated with cold and flu
- EXPECTORANT: Contains Guaifenesin, an expectorant that aids in thinning and loosening mucus for more productive coughs and chest congestion relief
- EXCESS MUCUS RELIEF: The expectorant, Guaifenesin, provides effective excess mucus relief by thinning and loosening bothersome mucus in your chest, helping to clear chest congestion
- COLD MEDICINE: Mucinex Rapid Clear Pain, Headache, & Mucus Congestion is a trusted cold medicine for adults, offering comprehensive relief from cold and flu symptoms including fever, body pain, sore throat, headache, and excess mucus
$13.97
5

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

GenCare

GenCare Nasal Decongestant PE – Phenylephrine HCl 10mg Tablets (Bulk 300 Count) Non-Drowsy Sinus Pressure Relief & Nasal Congestion Relief, Stuffy Nose Decongestants for Adults – Compare to Sudafed PE

GenCare

$9.99

More Details
Main highlights
- TARGETS SINUS PRESSURE – Provides fast temporary relief of swollen nasal membranes and sinus congestion pain, helping reduce facial pressure so you can feel comfortable and breathe normally again.
- PHENYLEPHRINE HCL 10MG – Works as a sinus decongestant by shrinking blood vessels in the nasal passages, helping to relieve stuffy nose and sinus pressure caused by colds, allergies, or seasonal head congestion.
- NON-DROWSY FORMULA – Over-the-counter sinus medicine designed to provide daytime sinus relief without making you sleepy. Enjoy symptom relief that won’t interrupt your day or slow you down.
- FAST NASAL CONGESTION RELIEF – These nasal decongestant tablets contain 10mg of Phenylephrine HCl, a powerful decongestant that helps reduce sinus pressure and nasal swelling so you can breathe easier with clearer airways.
- BULK SUPPLY, BULK SAVINGS – 300 count. GenCare offers the same active ingredient as Sudafed PE at a fraction of the price. Stock up and stay prepared for cold, allergy, and sinus flare-ups all year long.
$9.99

Best sinus medicines - May 2026

Sinus Infection Treatment & Symptoms | Request prescription for sinus medication like nasal spray, antibiotics for sinus headache & pain symptom relief from an online doctor, NP, or PA

Mucinex Maximum Strength Sinus-Max Severe Congestion & Pain + Nightshift Sinus Liquid, Cold and Flu Medicine for Adults, Over-the-Counter Medication for Multi-Symptom Relief, 2x6 Fl Oz

Sudafed PE Sinus Pressure Relief Plus Pain Relief Tablets, Maximum Strength, Non-Drowsy Decongestant, OTC Sinus Medicine with Acetaminophen and Phenylephrine HCl Nasal Decongestant, 24 CT

Mucinex Rapid Clear Maximum Strength Cold Medicine & Expectorant, Fever, Pain, Headache, & Excess Mucus Relief with Acetaminophen & Guaifenesin, Rapid Release Caplets for Adults, 20 Count

GenCare Nasal Decongestant PE – Phenylephrine HCl 10mg Tablets (Bulk 300 Count) Non-Drowsy Sinus Pressure Relief & Nasal Congestion Relief, Stuffy Nose Decongestants for Adults – Compare to Sudafed PE

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